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Excessive dosage of Rocaltrolcalcitriolinduces hypercalcemia and in some instances hypercalciuriathereforeearly in treatment during dosage adjustmentserum calcium should be determined twice weeklyIn dialysis patientsa fall in serum alkaline phosphatase levels usually antedates the appearance of hypercalcemia and may be an indication of impending hypercalcemiaAn abrupt increase in calcium intake as a result of changes in dietegincreased consumption of dairy productsor uncontrolled intake of calcium preparations may trigger hypercalcemia.

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Since Rocaltrolcalcitriolalso has an effect on phosphate transport in the intestinekidneys and bonesthe dosage of phosphate-binding agents must be adjusted in accordance with the serum phosphate concentration.

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