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Prescribing physicians must comply fully with the required safety measuresAt each consultationa patient receiving Clozaril must be reminded to contact the treating physician immediately if any kind of infection begins to developParticular attention must be paid to flu-like complaints such as fever or sore throat and to other evidence of infectionwhich may be indicative of neutropeniasee section 4.4

Do not stop taking clozapine without consulting your doctorSome conditions may become worse when the drug is suddenly stoppedAlsoyou may experience symptoms such as severe sweatingheadachenauseavomitingand diarrheaTo prevent these symptoms while you are stopping treatment with this drugyour doctor may reduce your dose graduallyConsult your doctor or pharmacist for more detailsReport any new or worsening symptoms right away.

An approximately 3-fold increased risk of cerebrovascular adverse events has been seen in randomised placebo controlled clinical trials in the dementia population with some atypical antipsychoticsThe mechanism for this increased risk is not knownAn increased risk cannot be excluded for other antipsychotics or other patient populationsClozapine should be used with caution in patients with risk factors for stroke.

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in contrast to more typical antipsychotic drugs, clozaril therapy produces little or no prolactin elevation.



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